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Important
Scientific Studies |
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- TheraBreath Eliminates Bad Breath on 25 subjects, under 3
Rigorous Tests.
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- British Study on the active ingredients in TheraBreath.
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- Long term study on patients who use TheraBreath as their
daily oral hygiene products.
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Use of
TheraBreath™ products in Bad Breath Patients:
(GCF and Halimeter Values, Effects of Oxygenized Saliva) |
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by: Drs. G. Acikgoz, I. Devrim, M. Aldikacti, A. Kayipmaz, G.
Keles - Professors of Periodontology at The Ondokuz Mayis
University Dental School, Department of Periodontology - Samsun,
Turkey |
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This independent study was presented abt the 4th International
Symposium on Oral Malodor, held at The University of California,
Los Angeles (UCLA) in August of 1999. |
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There are several etiological roles which play a role in the
ethiopathogenesis of bad breath. However, the major role is the
bacterial production of hydrogen sulphide. These anaerobic
bacteria live in areas where oxygen cannot reach them, including
the back of the throat and tongue, interproximal areas of the
teeth, periodontal pockets and enlarged tonsilla. A benefit to
those who suffer with bad breath would be the use of an
oxygenating agent which would eliminate the hydrogen sulphide
and the anaerobic bacteria. |
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Twenty-five subjects suffering with bad breath were treated with
TheraBreath brand stabilized chlorine dioxide mouthwash,
toothgel, and spray. Their progress was monitored by using 3
scientifically reproducible methods: |
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Flame Gas Chromatography, used to measure the production of
Volatile Sulphur Compounds in laboratories. |
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The Interscan Halimeter, which is used by some dentists to
monitor the production of sulphides in their dental offices. |
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Periotron 8000, which measures the concentration of anaerobic
bacteria and sulphides in collected saliva. |
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Results showed the following: |
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The Flame Gas Chromatography readings of Volatile Sulphur
Compounds decreased significantly following use of the products. |
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A statistically significant decrease in Halimeter readings,
showing that the oxygenating effect of TheraBreath reduced
volatile sulfur compounds. |
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Readings on the Periotron 8000 with regards to patient’s saliva
showed that TheraBreath had a beneficial effect. |
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Notes: This study was translated from Turkish so that it could
be presented at the 4th International Symposium on Oral Malodor,
August 20-21, 1999 at the University of California at Los
Angeles. |
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The
following independent study was performed over several weeks at
the office of Fred Heller DDS, San Francisco, CA on patients who
had bad breath and were then instructed on the use of
TheraBreath products. |
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Reduction of Oral Malodour by a Chlorine Dioxide Containing
Mouthrinse; Likely mechanisms of Action in Vivo |
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H. Chang, J.
Greenman, R. Allaker, and E. Lynch
Department of of Conservative Dentistry, Saint Bartholomew's and
the Royal London School of Medicine and Dentistry, QMW,
University of London and the University of West England,
Bristol, UK |
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The change in volatile sulfur compounds (VSC) levels
intraorally as recorded by a Halimeter was studied as a
potential method to investigate the mode of action and efficacy
of a chlorine dioxide (ClO2) mouthwash used as an anti-halitosis
agent. The Halimeter was used to monitor the levels of H2S
(hydrogen sulfide) every 2 minutes following a 0.1% (w/v)
cysteine mouthrinse, which was held in the mouth for one minute
prior to expectoration. |
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The results from an initial study with three participants showed
that the VSC response reached a maximum recorded level at either
4 or 6 minutes and returned to around baseline levels after
approximately 30 to 40 minutes. |
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Furthermore, a second cysteine mouthrinse applied within 1 to 2
hours following the first rinse gave a trend towards a larger
H2S response, indicating inducibility of VSC production. This
experiment involved application of a control rinse (water) on
day 1 and a chlorine dioxide rinse (test) on day 2, 75 minutes
following a first recorded cysteine-H2S response and one hour
prior to a second recorded cysteine-H2S response, on 20
participants. |
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The results showed that the second cysteine-H2S response was
significantly reduced (43% reduction; p< 0.05) following the
chlorine dioxide rinse test agent, compared to the water
control. These results indicate that the mechanism of action of
the chlorine dioxide reduction of VSC production is unlikely to
be primarily mediated by oxidation of substrate or VSC product. |
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Microbiological sampling of the tongue flora following cysteine,
water, and chlorine dioxide mouthrinses shoed no significant
differences in the recovery of aerobic, facultative anaerobic,
or strict anaerobic tongue species, suggesting that one of the
main mechanisms of action of chlorine dioxide may be
irreversible inhibition of the major cysteine to H2S enzyme,
cysteine desulfhydrase. |
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